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Article

Nuclear gene proximity and protein interactions shape transcript covariations in mammalian single cells.

Nature communications - 28 Oct 2020

Tarbier Marcel, Mackowiak Sebastian D, Frade João, Catuara-Solarz Silvina, Biryukova Inna, Gelali Eleni, Menéndez Diego Bárcena, Zapata Luis, Ossowski Stephan, Bienko Magda, Gallant Caroline J, Friedländer Marc R

Abstract excerpt

Single-cell RNA sequencing studies on gene co-expression patterns could yield important regulatory and functional insights, but have so far been limited by the confounding effects of differentiation and cell cycle. We apply a tailored experimental design that eliminates these confounders, and report thousands of intrinsically covarying gene pairs in mouse embryonic stem cells. These covariations form a network...

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Identifiers

PMID: 33116115
DOI: 10.1038/s41467-020-19011-5
PMCID: PMC7595044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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