Article

Proteome-wide copy-number estimation from transcriptomics

2023-07-11

Abstract excerpt

Protein copy numbers constrain systems-level properties of regulatory networks, but absolute proteomic data remain scarce compared to transcriptomics obtained by RNA sequencing. We addressed this persistent gap by relating mRNA to protein statistically using best-available data from quantitative proteomics–transcriptomics for 4366 genes in 369 cell lines. The approach starts with a central estimate of protein copy...

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Literature Corpus work: c8b79bc6-760c-58cf-b1bf-196045d5c772
DOI: 10.1101/2023.07.10.548432

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