Combined mRNA and protein single cell analysis in a dynamic cellular system using SPARC

Abstract excerpt

<h4>ABSTRACT</h4> Combined measurements of mRNA and protein expression in single cells enables in-depth analysis of cellular states. We present single-cell protein and RNA co-profiling (SPARC), an approach to simultaneously measure global mRNA and large sets of intracellular protein in individual cells. Using SPARC, we show that mRNA expression fails to accurately reflect protein abundance at the time of measurem...

Topics

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• DNA Repair
• Gene Expression
• Genomics
• High-Throughput Nucleotide Sequencing
• Lymphocytes
• RNA, Messenger
• RNA-Seq
• Single-Cell Analysis

Identifiers and source

Literature Corpus work

3efabbf9-b3b0-5bd1-8804-b9368caafc62

DOI

10.1101/749473