Article

TMEM174 Deficiency Reduces Longevity by Promoting Phosphate-Driven Vascular Calcification

2026-04-14

Abstract excerpt

<h4>Background</h4> Dysregulation of phosphate homeostasis contributes to reduced longevity and vascular complications in chronic kidney disease and aging. This study investigates the role of TMEM174, a proximal tubule-specific protein, in regulating the phosphate co-transporter NPT2A and its subsequent impact on lifespan and vascular health. <h4>Methods</h4> TMEM174 knockout (KO) mice (C57BL6/J and DBA/2J) were...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cdc86b03-985d-59d2-96e8-e1e405174de2
DOI: 10.64898/2026.04.09.716713

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TMEM174 Deficiency Reduces Longevity by Promoting Phosphate-Driven Vascular CalcificationDOI 10.64898/2026.04.09.716713Read

TMEM174 Deficiency Reduces Longevity by Promoting Phosphate-Driven Vascular CalcificationSemantic proximity Read

Structural and mechanistic insights into SLC34 phosphate importSemantic proximity Read

Calorie restriction leads to degradation of mutant uromodulin and ameliorates inflammation and fibrosis in <i>UMOD</i> -related kidney diseaseSemantic proximity Read

TMEM175 plays a crucial role in osteoblast differentiation by regulating lysosomal function and autophagy.Semantic proximity Read

MANF Clears Mutant Uromodulin in Human Kidney Organoids of Autosomal Dominant Tubulointerstitial Kidney DiseaseSemantic proximity Read

Noncanonical Sequences Involving NHERF1 Interaction with NPT2A Govern Hormone-Regulated Phosphate Transport: Binding Outside the Box.Semantic proximity Read

Modeling pulmonary alveolar microlithiasis by epithelial deletion of the Npt2b sodium phosphate cotransporter reveals putative biomarkers and strategies for treatment.Semantic proximity Read

Calorie Restriction Leads to Degradation of Mutant Uromodulin and Ameliorates Inflammation and Fibrosis in UMOD -Related Kidney Disease.Semantic proximity Read

Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging.Semantic proximity Read

Phosphoproteomic Analysis Reveals Regulatory Mechanisms at the Kidney Filtration BarrierSemantic proximity Read

Mutations in an unrecognized internal NPT2A PDZ motif disrupt phosphate transport and cause congenital hypophosphatemia.Semantic proximity Read

Microvasculopathy, Luminal Calcification and Premature Aging in Fetuin-A Deficient MiceSemantic proximity Read