Calorie Restriction Leads to Degradation of Mutant Uromodulin and Ameliorates Inflammation and Fibrosis in UMOD -Related Kidney Disease.

Abstract excerpt

KEY POINTS: Calorie restriction stimulated autophagy and degradation of mutant uromodulin, leading to amelioration of cell stress and tubular damage. At early disease stage, calorie restriction largely reverted autosomal dominant tubulointerstitial kidney disease (ADTKD)- UMOD phenotype, preventing inflammation, fibrosis, and kidney function decline. At advanced disease stage, calorie restriction significantly...

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