Article

TMEM174 Deficiency Reduces Longevity by Promoting Phosphate-Driven Vascular Calcification

2026-06-01

Abstract excerpt

<title>Abstract</title> <p>Dysregulation of phosphate homeostasis contributes to reduced longevity and vascular complications in chronic kidney disease and aging. This study investigates the role of TMEM174, a proximal tubule-specific protein, in regulating the phosphate co-transporter NPT2A and its subsequent impact on lifespan and vascular health. TMEM174 knockout (KO) mice (C57BL6/J and DBA/2J) were fed diets...

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Literature Corpus work: 225307c5-c269-5199-b408-8925996506ce
DOI: 10.21203/rs.3.rs-9857363/v1

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