Article

Calorie restriction leads to degradation of mutant uromodulin and ameliorates inflammation and fibrosis in <i>UMOD</i> -related kidney disease

2025-12-19

Abstract excerpt

<h4>Background</h4> Mutations in UMOD , encoding uromodulin, lead to Autosomal Dominant Tubulointerstitial Kidney Disease (ADTKD), a genetic cause of kidney failure. UMOD mutations have a common gain-of-toxic-function effect, causing mutant uromodulin retention in the endoplasmic reticulum (ER). This leads to ER stress, alteration of protein homeostasis and mitochondrial dynamics, defective autophagy and increa...

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Literature Corpus work: 202fcd0a-0514-542c-aaa8-f38b988ac069
DOI: 10.64898/2025.12.16.694693

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