Article

Microvasculopathy, Luminal Calcification and Premature Aging in Fetuin-A Deficient Mice

2019-03-14

Abstract excerpt

<h4>Objective</h4> The plasma protein fetuin-A mediates the formation of protein-mineral colloids known as calciprotein particles (CPP) – rapid clearance of these CPP by the reticuloendothelial system prevents errant mineral precipitation and therefore ectopic mineralization (calcification). The mutant mouse strain D2, Ahsg-/- combines fetuin-A deficiency with the mineralization-prone DBA/2 genetic background, h...

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Literature Corpus work: d73eeb15-ce0e-5616-8f48-c4701ea07be0
DOI: 10.1101/577098

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