Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Combining phenomics with transcriptomics reveals cell-type-specific morphological and molecular signatures of the 22q11.2 deletion

9 Jul 2025

Abstract excerpt

Neuropsychiatric disorders remain difficult to treat due to complex and poorly understood mechanisms. NeuroPainting is a high-content morphological profiling assay based on Cell Painting and optimized for human stem cell–derived neural cell types, including neurons, progenitors, and astrocytes. The assay quantifies over 4000 features of cell structure and organelle organization, generating a dataset suitable for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiac Fibrosis and Remodeling
Share to Congenital heart defects research
Share to Genomics and Phylogenetic Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40634302
DOI: 10.1038/s41467-025-61547-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Combining phenomics with transcriptomics reveals cell-type-specific morphological and molecular signatures of the 22q11.2 deletionPMID 40634302Read ↗

Combining NeuroPainting with transcriptomics reveals cell-type-specific morphological and molecular signatures of the 22q11.2 deletionSemantic proximity Read ↗

A genome-wide atlas of human cell morphologySemantic proximity Read ↗

Joint profiling of cell morphology and gene expression during <i>in vitro</i> neurodevelopmentSemantic proximity Read ↗

High-dimensional phenotyping to define the genetic basis of cellular morphologySemantic proximity Read ↗

Image-based, pooled phenotyping reveals multidimensional, disease-specific variant effectsSemantic proximity Read ↗

A Transcriptomic Atlas of the Human Brain Reveals Genetically Determined Aspects of Neuropsychiatric HealthSemantic proximity Read ↗

Image-based, pooled phenotyping reveals multidimensional, disease-specific variant effects.Semantic proximity Read ↗

Aberrant pace of cortical neuron development in brain organoids from patients with 22q11.2 deletion syndrome-associated schizophreniaSemantic proximity Read ↗

Cell type mapping of mild malformations of cortical development with oligodendroglial hyperplasia in epilepsy using single-nucleus multiomicsSemantic proximity Read ↗

Image-Based Profiling of Induced Trophoblast Stem Cells Identifies Signatures Associated with Sex, Schizophrenia Genomic Risk and Placental StressSemantic proximity Read ↗

Mapping variation in the morphological landscape of human cells with optical pooled CRISPRi screeningSemantic proximity Read ↗

CelltypeR: A flow cytometry pipeline to annotate, characterize and isolate single cells from brain organoidsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.