Article

High-dimensional phenotyping to define the genetic basis of cellular morphology

2023-01-09

Abstract excerpt

The morphology of cells is dynamic and mediated by genetic and environmental factors. Characterizing how genetic variation impacts cell morphology can provide an important link between disease association and cellular function. Here, we combined genomic and high-content imaging approaches on iPSCs from 297 unique donors to investigate the relationship between genetic variants and cellular morphology to map what we...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d9d76114-d3c0-5aa8-aa62-d63db0534151
DOI: 10.1101/2023.01.09.522731

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

High-dimensional phenotyping to define the genetic basis of cellular morphologyDOI 10.1101/2023.01.09.522731Read

Cellular morphology emerges from polygenic, distributed transcriptional variationSemantic proximity Read

Combining NeuroPainting with transcriptomics reveals cell-type-specific morphological and molecular signatures of the 22q11.2 deletionSemantic proximity Read

A genome-wide atlas of human cell morphologySemantic proximity Read

Combining phenomics with transcriptomics reveals cell-type-specific morphological and molecular signatures of the 22q11.2 deletionSemantic proximity Read

Single-cell morphology encodes metastatic potential.Semantic proximity Read

Morphological map of under- and over-expression of genes in human cellsSemantic proximity Read

Cell shapes decode molecular phenotypes in image-based spatial proteomicsSemantic proximity Read

Joint profiling of cell morphology and gene expression during <i>in vitro</i> neurodevelopmentSemantic proximity Read

Robust integrated intracellular organization of the human iPS cell: where, how much, and how variableSemantic proximity Read

Image-based, pooled phenotyping reveals multidimensional, disease-specific variant effects.Semantic proximity Read

Pathogenic Morphological Signatures of Perturbations in Mitochondrial-Related Genes Revealed by Pooled Imaging AssaySemantic proximity Read

Image-based, pooled phenotyping reveals multidimensional, disease-specific variant effectsSemantic proximity Read