Article

Reprogramming of serine metabolism is an actionable vulnerability in <i>FLT3</i> - <i>ITD</i> driven acute myeloid leukaemia

2020-05-27

Abstract excerpt

Activating FMS-like tyrosine kinase 3 ( FLT3 ) mutations occur in approximately 30% of all acute myeloid leukaemias (AMLs) and are associated with poor prognosis. The limited clinical efficacy of FLT3 inhibitor monotherapy has highlighted the need for alternative therapeutic targets and treatments for FLT3-mutant AML. Using human and murine models of MLL-rearranged AML harbouring FLT3 internal tandem duplication...

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Literature Corpus work: cd93d70d-9b34-56c7-aa8c-013398951d78
DOI: 10.1101/2020.05.26.116392

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