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Article

Oncogenic FLT3 internal tandem duplication activates E2F1 to regulate purine metabolism in acute myeloid leukaemia.

Biochemical pharmacology - 1 Apr 2023

Ou Zi-Yao, Wang Ke, Shen Wen-Wen, Deng Ge, Xu Ya-Yun, Wang Long-Fei, Zai Zhuo-Yan, Ling Yi-An, Zhang Tao, Peng Xiao-Qing, Chen Fei-Hu

Abstract excerpt

Oncogene FLT3 internal tandem duplication (FLT3-ITD) mutation accounts for 30 % of acute myeloid leukaemia (AML) cases and induces transformation. Previously, we found that E2F transcription factor 1 (E2F1) was involved in AML cell differentiation. Here, we reported that E2F1 expression was aberrantly upregulated in AML patients, especially in AML patients carrying FLT3-ITD. E2F1 knockdown inhibited cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36803956
DOI: 10.1016/j.bcp.2023.115458

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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