Article

E2F1 activation by oncogenic FLT3 internal tandem duplication in regulating purine metabolism in acute myeloid leukaemia

2022-09-08

Abstract excerpt

Oncogene FLT3 internal tandem duplication (FLT3-ITD) mutation account for up to 30% of acute myeloid leukaemia (AML) cases and induce transformation.Previously, we found that E2F transcription factor 1 (E2F1) is involved in autophagy in the AML cell line MOLM-13, which harboring the FLT3-ITD. Here, we reported that E2F1 expression was gradually decreased during normal haematopoiesis but was aberrantly upregulated...

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Literature Corpus work: 1f9b866f-43d5-55c6-b3d5-75df7d4bae5b
DOI: 10.21203/rs.3.rs-2016769/v1

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