Article

Neuroprotective effects of Canagliflozin: lessons from aged genetically diverse UM-HET3 mice

2022-01-28

Abstract excerpt

The aging brain is characterized by a progressive increase in neuroinflammation and central insulin resistance, which contribute to neurodegenerative diseases and cognitive impairment. Recently, the Interventions Testing Program (ITP) demonstrated that the anti-diabetes drug, Canagliflozin (Cana), a sodium-glucose transporter 2 inhibitor (SGLT2i), led to lower fasting glucose and improved glucose tolerance in both...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5f6e1a73-8822-550d-92b2-db2787d9be5b
DOI: 10.1101/2022.01.27.478017

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Neuroprotective effects of Canagliflozin: lessons from aged genetically diverse UM-HET3 miceDOI 10.1101/2022.01.27.478017Read

Canagliflozin reprograms the aging hippocampus in genetically diverse UM-HET3 mice and attenuates Alzheimer’s-like pathologySemantic proximity Read

Canagliflozin Extends Lifespan in Genetically Heterogeneous Male But Not Female MiceSemantic proximity Read

Role of sex and high fat diet in metabolic and hypothalamic disturbances in the 3xTg-AD mouse model of Alzheimer’s diseaseSemantic proximity Read

Sex differences in metabolic phenotype and hypothalamic inflammation in the 3xTg-AD mouse model of Alzheimer's disease.Semantic proximity Read

Metformin acts directly in the brain to slow features of neurodegenerationSemantic proximity Read

Age- and sex-associated alterations in hypothalamic mitochondrial bioenergetics and inflammatory-associated signaling in the 3xTg mouse model of Alzheimer’s diseaseSemantic proximity Read

Metformin improves cognition of aged mice by promoting cerebral angiogenesis and neurogenesisSemantic proximity Read

Human hypothalamic neural stem cells transplantation ameliorates age-associated dysfunction through SNS/eNAMPT axis activation in aged miceSemantic proximity Read

A ketogenic diet reduces age-induced chronic neuroinflammation in miceSemantic proximity Read

Orally active mGluR2/3 metabotropic antagonist pro-drug mimics the beneficial effects of physical exercise on neurogenesis, behavior, and exercise-related molecular pathways in an Alzheimer’s disease mouse modelSemantic proximity Read

Dysregulated mTOR networks in experimental sporadic Alzheimer’s diseaseSemantic proximity Read

Hyperglycemia and cognitive impairments anticipate the onset of an overt type 2 diabetes-like phenotype in TALLYHO/JngJ mice.Semantic proximity Read