Article

Canagliflozin Extends Lifespan in Genetically Heterogeneous Male But Not Female Mice

2020-05-26

Abstract excerpt

Canagliflozin (Cana) is an inhibitor of the sodium glucose transporter 2 (SGLT2), and is thought to act by blocking renal reuptake and intestinal absorption of glucose. Cana is FDA-approved for treatment of diabetes, and affords protection from cardiovascular and kidney diseases. In the context of the mouse Interventions Testing Program, genetically heterogeneous mice were given chow containing 180 ppm Cana at 7 m...

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Literature Corpus work: 68a6369f-5fb4-5ab9-b45d-e5f1ccf72e12
DOI: 10.1101/2020.05.23.112763

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