Article

The essential roles of Dicer-mediated mTORC1 signaling in parathyroid gland integrity and function: Insights from genetic mouse models and clinical data

2023-08-22

Abstract excerpt

Secondary hyperparathyroidism (SHP) frequently accompanies chronic kidney disease (CKD), contributing to morbidity and mortality in patients. Our previous findings demonstrated that PT- Dicer -/- mice, with parathyroid specific deletion of Dicer and consequently microRNA, maintained normal serum PTH levels but failed to increase serum PTH in response to the major inducers of PTH secretion, hypocalcemia and CKD....

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Literature Corpus work: cd7702ea-13d3-5d26-9540-50e9f1de506d
DOI: 10.1101/2023.08.21.554016

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