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Article

Unraveling the Mechanistic Complexity of the Glomerulocystic Phenotype in Dicer Conditional KO Mice by 2D Gel Electrophoresis Coupled Mass Spectrometry.

Proteomics. Clinical applications - 1 May 2018

Fiumara Claudia Vincenza, Scumaci Domenica, Iervolino Anna, Perri Angela Mena, Concolino Antonio, Tammè Laura, Petrillo Federica, Capasso Giovambattista, Cuda Giovanni

Abstract excerpt

PURPOSE: Dicer, an RNase III type endonuclease, is a key enzyme involved in miRNA biogenesis. It has been shown that this enzyme is essential for several aspects of postnatal kidney functions and homeostasis. In this study, we have examined conditional knockout (cKO) mice for Dicer in Pax8 (Paired-box gene 8) expressing cells to investigate the kidney protein profile. This specific model develops a...

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Share to DEAD-box RNA Helicases
Share to Electrophoresis, Gel, Two-Dimensional

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Kidney Diseases, Cystic

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Share to Mitogen-Activated Protein Kinase 1

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Source

Identifiers

PMID: 29159954
DOI: 10.1002/prca.201700006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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