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Article

Activation of mTORC1 in collecting ducts causes hyperkalemia.

Journal of the American Society of Nephrology : JASN - 1 Mar 2014

Chen Zhenguo, Dong Heling, Jia Chunhong, Song Qiancheng, Chen Juan, Zhang Yue, Lai Pinglin, Fan Xiaorong, Zhou Xuan, Liu Miao, Lin Jun, Yang Cuilan, Li Ming, Gao Tianming, Bai Xiaochun

Abstract excerpt

Mutation of TSC (encoding tuberous sclerosis complex protein) and activation of mammalian target of rapamycin (mTOR) have been implicated in the pathogenesis of several renal diseases, such as diabetic nephropathy and polycystic kidney disease. However, the role of mTOR in renal potassium excreti...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24203997
DOI: 10.1681/ASN.2013030225
PMCID: PMC3935580

Genes

TSC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24203997-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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