Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Suppression of microRNA Activity in Kidney Collecting Ducts Induces Partial Loss of Epithelial Phenotype and Renal Fibrosis.

Journal of the American Society of Nephrology : JASN - 1 Feb 2018

Hajarnis Sachin, Yheskel Matanel, Williams Darren, Brefort Thomas, Glaudemans Bob, Debaix Huguette, Baum Michel, Devuyst Olivier, Patel Vishal

Abstract excerpt

microRNAs (miRNAs) are sequence-specific inhibitors of post-transcriptional gene expression. The physiologic function of these noncoding RNAs in postnatal renal tubules still remains unclear. Surprisingly, they appear to be dispensable for mammalian proximal tubule (PT) function. Here, we examined the effects of miRNA suppression in collecting ducts (CDs). To conclusively evaluate the role of miRNAs, we generated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Argonaute Proteins
Share to Eukaryotic Initiation Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kidney Tubules, Collecting

Share to Kidney Tubules, Proximal

Share to Ribonuclease III

Share to Snail Family Transcription Factors

Share to Zinc Finger E-box-Binding Homeobox 1

Share to Zinc Finger E-box Binding Homeobox 2

Source

Open in PubMed Open full text

Identifiers

PMID: 29021386
DOI: 10.1681/ASN.2017030334
PMCID: PMC5791084

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Suppression of microRNA Activity in Kidney Collecting Ducts Induces Partial Loss of Epithelial Phenotype and Renal Fibrosis.PMID 29021386Read ↗

Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidney.Semantic proximity Read ↗

Podocyte-specific loss of functional microRNAs leads to rapid glomerular and tubular injury.Semantic proximity Read ↗

MicroRNAs Regulate Renal Tubule Maturation through Modulation of Pkd1Semantic proximity Read ↗

Podocyte-Specific Deletion of Dicer Alters Cytoskeletal Dynamics and Causes Glomerular DiseaseSemantic proximity Read ↗

Renal stromal miRNAs are required for normal nephrogenesis and glomerular mesangial survivalSemantic proximity Read ↗

Loss of Dgcr8-mediated microRNA expression in the kidney results in hydronephrosis and renal malformation.Semantic proximity Read ↗

Targeted sequencing of 96 renal developmental microRNAs in 1213 individuals from 980 families with congenital anomalies of the kidney and urinary tract.Semantic proximity Read ↗

Small non-coding RNA expression in developing mouse nephron progenitor cellsSemantic proximity Read ↗

The function of miRNAs in the process of kidney developmentSemantic proximity Read ↗

Role of microRNAs in Renal Parenchymal Diseases—A New DimensionSemantic proximity Read ↗

The essential roles of Dicer-mediated mTORC1 signaling in parathyroid gland integrity and function: Insights from genetic mouse models and clinical dataSemantic proximity Read ↗

Mice lacking microRNAs in Pax8-expressing cells develop hypothyroidism and end-stage renal failure.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.