Article

Mechanism of cystogenesis by Cd79a-driven, conditional mTOR activation in developing mouse nephrons

2022-10-10

Abstract excerpt

Polycystic kidney disease (PKD) is a common genetic disorder arising from developmental and postnatal processes. Defects in primary cilia and their signaling (eg, mTOR) underlie the pathogenesis. However, how mTOR regulates tubular integrity remains unclear. The paucity of faithful models has limited our understanding of pathogenesis and, therefore, the refinement of therapeutic targets. To understand the role of...

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Literature Corpus work: 6800c6e2-94d7-519c-94d8-0dadae412921
DOI: 10.21203/rs.3.rs-2126642/v1

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