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Article

MicroRNAs Regulate Renal Tubule Maturation through Modulation of Pkd1

8 Nov 2012

Abstract excerpt

MicroRNAs (miRNAs) contribute to the regulation of early kidney development, but their role during later stages of renal tubule maturation is not well understood. Here, we found that ablation of the miRNA-processing enzyme Dicer from maturing renal tubules produces tubular and glomerular cysts in mice. Inactivation of Dicer is associated with downregulation of miR-200, a kidney-enriched miRNA family, and...

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PMID: 23138483
DOI: 10.1681/asn.2012030321

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