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Mutant mice lacking alternatively spliced p53 isoforms unveil Ackr4 as a male-specific prognostic factor in Myc-driven B-cell lymphomas

2023-10-18

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The Trp53 gene encodes several isoforms of elusive biological significance. Here we show that mice lacking the Trp53 Alternatively Spliced (AS) exon, thereby expressing the canonical p53 protein but not isoforms with the AS C-terminus, have unexpectedly lost a male-specific protection against Myc-induced B-cell lymphomas. Lymphomagenesis was delayed in p53 +/+ Eμ-Myc males compared to p53 ΔAS/ΔAS Eμ-Myc males,...

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Literature Corpus work: cd6973e6-7e1a-5563-a809-7456e5d2461f
DOI: 10.1101/2023.10.13.562180

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Mutant mice lacking alternatively spliced p53 isoforms unveil <i>Ackr4</i> as a male-specific prognostic factor in Myc-driven B-cell lymphomas

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