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Induced p53 loss in mouse luminal cells causes clonal expansion and development of mammary tumours

13 Feb 2017

Abstract excerpt

Abstract Most breast cancers may have a luminal origin. TP53 is one of the most frequently mutated genes in breast cancers. However, how p53 deficiency contributes to breast tumorigenesis from luminal cells remains elusive. Here we report that induced p53 loss in Krt8 + mammary luminal cells leads to their clonal expansion without directly affecting their luminal identity. All induced mice develop mammary tumours...

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PMID: 28194015
DOI: 10.1038/ncomms14431

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