Article
Loss of p73 promotes dissemination of Myc-induced B cell lymphomas in mice.
The Journal of clinical investigation - 1 Jun 2010
Nemajerova Alice, Petrenko Oleksi, Trümper Lorenz, Palacios Gustavo, Moll Ute M
Abstract excerpt
Mice engineered to express c-Myc in B cells (Emu-myc mice) develop lethal lymphomas in which the gene encoding the p53 tumor suppressor is frequently mutated. Whether the p53 homolog p73 also functions as a tumor suppressor in vivo remains controversial. Here we have shown that p73 loss does not substantially affect disease onset and mortality in Emu-myc mice. However, it does alter the phenotype of the disease....
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