Article

AlphaGenome deletion responses complement supervised enhancer–gene relation prediction in primary human astrocytes

2026-08-19

Abstract excerpt

Sequence-to-function models predict molecular readouts directly from DNA, but recognizing a functional regulatory element is not equivalent to assigning the gene it regulates. We evaluated whether AlphaGenome deletion responses identify experimentally supported enhancer–gene relations, using a frozen K562 analysis and a primary-human-astrocyte CRISPR interference (CRISPRi) resource external to our analysis. The K5...

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Literature Corpus work: cd65648c-6954-5a60-9024-231ab643f3e9
DOI: 10.64898/2026.08.14.744988

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