Maturing autophagosomes are transported towards the cell periphery

Abstract excerpt

<title>Abstract</title> <p>Autophagosome maturation comprises fusion with lysosomes and acidification. It is a critical step in the degradation of cytosolic protein aggregates that characterize many neurodegenerative diseases. In order to better understand this process, we studied intracellular trafficking of autophagosomes and aggregates of α-synuclein, which characterize Parkinson’s disease and other synucleino...

Topics

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• Autophagy in Disease and Therapy
• Autophagy-Related Protein 5
• Cellular transport and secretion
• Endoplasmic Reticulum Stress and Disease
• Endosomes
• Lysosomal-Associated Membrane Protein 1
• Lysosomal-Associated Membrane Protein 2
• Membrane Fusion

Identifiers and source

Literature Corpus work

cd5669ea-8dc0-57ad-b045-77a6f7030baf

DOI

10.21203/rs.3.rs-200706/v1