Article

Atg4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system

2020-12-18

Abstract excerpt

<h4>Summary</h4> The sequestration of damaged mitochondria within double-membrane structures termed autophagosomes is a key step of PINK1/Parkin mitophagy. The Atg4 family of proteases are thought to regulate autophagosome formation exclusively by processing the ubiquitin-like Atg8 family (LC3/GABARAPs). We make the unexpected discovery that human Atg4s can directly promote autophagosome formation independently o...

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Literature Corpus work: 1887d9b4-7c37-5074-acdd-1f364e9b778b
DOI: 10.1101/2020.12.17.422596

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