Article

Targeting Lysosomal pH Restores Mitochondrial Quality Control in GBA1-Mutant Parkinson’s Disease

2025-09-02

Abstract excerpt

<h4>Background</h4> Heterozygous mutations in the Glucocerebrosidase gene ( GBA1 ), which encodes the lysosomal enzyme β-glucocerebrosidase (GCase), are a genetic risk factor for Parkinson’s disease (PD). The pathophysiological consequences of GBA1 mutations on dopaminergic neuronal function, especially their impact on lysosomal function, mitophagy, and mitochondrial bioenergetics, remain unclear. <h4>Methods<...

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Literature Corpus work: 39da3e44-3eb9-5945-8372-406702307597
DOI: 10.1101/2025.08.28.672738

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