Article

Targeting Lysosomal pH Restores Mitochondrial Quality Control in GBA1-Mutant Parkinson’s Disease

2025-10-08

Abstract excerpt

<title>Abstract</title> <p> Background Heterozygous mutations in the Glucocerebrosidase gene ( <italic>GBA1</italic> ), which encodes the lysosomal enzyme β-glucocerebrosidase (GCase), are a genetic risk factor for Parkinson’s disease (PD), characterised by lysosomal dysfunction. The pathological effects of <italic>GBA1</italic> mutations on PD, especially their influence on lysosomal function, mitophagy, an...

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Literature Corpus work: fb0b9555-095a-54fe-a892-95800a68c5d6
DOI: 10.21203/rs.3.rs-7558589/v1

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