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Article

Understanding rare and common diseases in the context of human evolution.

Genome biology - 7 Nov 2016

Quintana-Murci Lluis

Abstract excerpt

The wealth of available genetic information is allowing the reconstruction of human demographic and adaptive history. Demography and purifying selection affect the purge of rare, deleterious mutations from the human population, whereas positive and balancing selection can increase the frequency of advantageous variants, improving survival and reproduction in specific environmental conditions. In this review, I...

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Identifiers

PMID: 27821149
DOI: 10.1186/s13059-016-1093-y
PMCID: PMC5098287

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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