Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sex-specific genetic architecture of human disease.

Nature reviews. Genetics - 1 Dec 2008

Ober Carole, Loisel Dagan A, Gilad Yoav

Abstract excerpt

Sexual dimorphism in anatomical, physiological and behavioural traits are characteristics of many vertebrate species. In humans, sexual dimorphism is also observed in the prevalence, course and severity of many common diseases, including cardiovascular diseases, autoimmune diseases and asthma. Although sex differences in the endocrine and immune systems probably contribute to these observations, recent studies...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asthma
Share to Autoimmune Diseases
Share to Cardiovascular Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease

Share to Gene Expression Regulation

Share to Genetic Predisposition to Disease

Share to Quantitative Trait Loci

Share to Sex Characteristics

Source

Open in PubMed Open full text

Identifiers

PMID: 19002143
DOI: 10.1038/nrg2415
PMCID: PMC2694620

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sex-specific genetic architecture of human disease.PMID 19002143Read ↗

The evolution of sex differences in disease geneticsSemantic proximity Read ↗

Sex differences in disease geneticsSemantic proximity Read ↗

The evolution of sex differences in diseaseSemantic proximity Read ↗

Sex difference in human diseases: mechanistic insights and clinical implicationsSemantic proximity Read ↗

Genetic Architecture of Sexual Dimorphism in HumansSemantic proximity Read ↗

Sexual differences in genetic architecture in UK BiobankSemantic proximity Read ↗

The landscape of sex-differential transcriptome and its consequent selection in human adultsSemantic proximity Read ↗

Sex differences in disease genetics: evidence, evolution, and detection.Semantic proximity Read ↗

Quality control and analytic best practices for testing genetic models of sex differences in large populations.Semantic proximity Read ↗

Evidence for sex-specific genetic architectures across a spectrum of human complex traits.Semantic proximity Read ↗

The impact of sex differences on genomic researchSemantic proximity Read ↗

The sex-specific genetic architecture of quantitative traits in humans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.