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Article

Polygenic signals of sex differences in selection in humans from the UK Biobank.

PLoS biology - 1 Sept 2022

Ruzicka Filip, Holman Luke, Connallon Tim

Abstract excerpt

Sex differences in the fitness effects of genetic variants can influence the rate of adaptation and the maintenance of genetic variation. For example, "sexually antagonistic" (SA) variants, which are beneficial for one sex and harmful for the other, can both constrain adaptation and increase genetic variability for fitness components such as survival, fertility, and disease susceptibility. However, detecting...

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PMID: 36067235
DOI: 10.1371/journal.pbio.3001768
PMCID: PMC9481184

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