Article

Disruption of undecaprenyl phosphate recycling suppresses <i>ampC</i> beta-lactamase induction in <i>Pseudomonas aeruginosa</i>

2025-06-05

Abstract excerpt

<h4>ABSTRACT</h4> Beta-lactam antibiotics are widely used to treat bacterial infections, but their efficacy is compromised by resistance mechanisms such as the production of beta-lactamases. In Pseudomonas aeruginosa , the chromosomally encoded beta-lactamase AmpC is the primary mediator of beta-lactam resistance. ampC expression is regulated by the transcription factor AmpR, which responds to intracellular pep...

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Literature Corpus work: cd008daa-d8e9-538b-a905-056dd73fe5a5
DOI: 10.1101/2025.06.03.657773

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