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Article

Role of Pseudomonas aeruginosa low-molecular-mass penicillin-binding proteins in AmpC expression, β-lactam resistance, and peptidoglycan structure.

Antimicrobial agents and chemotherapy - 1 Jul 2015

Ropy Alaa, Cabot Gabriel, Sánchez-Diener Irina, Aguilera Cristian, Moya Bartolome, Ayala Juan A, Oliver Antonio

Abstract excerpt

This study aimed to characterize the role of Pseudomonas aeruginosa low-molecular-mass penicillin-binding proteins (LMM PBPs), namely, PBP4 (DacB), PBP5 (DacC), and PBP7 (PbpG), in peptidoglycan composition, β-lactam resistance, and ampC regulation. For this purpose, we constructed all single and multiple mutants of dacB, dacC, pbpG, and ampC from the wild-type P. aeruginosa PAO1 strain. Peptidoglycan composition...

Topics

Anti-Bacterial Agents
Bacterial Proteins
Boron Compounds
Carboxypeptidases
Cell Membrane
Gene Knockout Techniques
Microbial Sensitivity Tests
Mutation
Penicillin-Binding Proteins
Penicillins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Peptidoglycan

Pseudomonas aeruginosa

beta-Lactam Resistance

beta-Lactamases

beta-Lactams

Source

Open in PubMed Open full text

Identifiers

PMID: 25896695
DOI: 10.1128/AAC.05150-14
PMCID: PMC4468666

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