A potential space-making role in cell wall biogenesis for SltB1and DacB revealed by a beta-lactamase induction phenotype in Pseudomonas aeruginosa.

doi:10.1128/mbio.01419-24

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Article

A potential space-making role in cell wall biogenesis for SltB1and DacB revealed by a beta-lactamase induction phenotype in Pseudomonas aeruginosa.

mBio - 17 Jul 2024

Gyger Joël, Torrens Gabriel, Cava Felipe, Bernhardt Thomas G, Fumeaux Coralie

Abstract excerpt

Pseudomonas aeruginosa encodes the beta-lactamase AmpC, which promotes resistance to beta-lactam antibiotics. Expression of ampC is induced by anhydro-muropeptides (AMPs) released from the peptidoglycan (PG) cell wall upon beta-lactam treatment. AmpC can also be induced via genetic inactivation of PG biogenesis factors such as the endopeptidase DacB that cleaves PG crosslinks. Mutants in dacB occur in...

Topics

Pseudomonas aeruginosa
Cell Wall
beta-Lactamases
Bacterial Proteins
beta-Lactam Resistance
Phenotype
Peptidoglycan
Anti-Bacterial Agents
beta-Lactams
Gene Expression Regulation, Bacterial

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Identifiers

PMID: 38920394
DOI: 10.1128/mbio.01419-24
PMCID: PMC11253642

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