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Article

Providing β-lactams a helping hand: targeting the AmpC β-lactamase induction pathway.

Future microbiology - 1 Dec 2011

Mark Brian L, Vocadlo David J, Oliver Antonio

Abstract excerpt

A major cause of the clinical failure of broad-spectrum β-lactam antibiotics against Pseudomonas aeruginosa and many Enterobacteriaceae species are chromosomal mutations that lead to the hyperproduction of AmpC β-lactamase. These mutations typically affect proteins within the peptidoglycan (PG) recycling pathway, as well as proteins that are modulated by metabolic intermediates of this pathway. Blocking PG...

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Source

Identifiers

PMID: 22122439
DOI: 10.2217/fmb.11.128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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