Article

Background covariance adjustment distills shared genetic architecture across neurodevelopmental and neurodegenerative disorders

2026-03-09

Abstract excerpt

<h4>ABSTRACT</h4> GWAS increasingly reveal shared genetic influences across neurodevelopmental, psychiatric, and neurodegenerative traits. However, cross-trait genetic covariance derived from GWAS summary statistics can be inflated by sample overlap and other structured background effects, obscuring higher-order genetic organization. We extend PathGPS, a recently developed statistical method that estimates an adj...

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Literature Corpus work: ccdf8455-088c-588d-8eb2-2ae7c4046c3d
DOI: 10.64898/2026.03.08.26347891

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