Article

Novel genomic loci influence patterns of structural covariance in the human brain

2022-07-22

Abstract excerpt

Normal and pathologic neurobiological processes influence brain morphology in coordinated ways that give rise to patterns of structural covariance (PSC) across brain regions and individuals during brain aging and diseases. The genetic underpinnings of these patterns remain largely unknown. We apply a stochastic multivariate factorization method to a diverse population of 50,699 individuals (12 studies, 130 sites)...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8bbdaea8-7e8e-5217-9084-bb8916e244ad
DOI: 10.1101/2022.07.20.22277727

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Novel genomic loci influence patterns of structural covariance in the human brainDOI 10.1101/2022.07.20.22277727Read

Mega-analysis of brain structural covariance, genetics, and clinical phenotypesSemantic proximity Read

Genomic Structural Equation Modeling Reveals Latent Phenotypes in the Human Cortex with Distinct Genetic ArchitectureSemantic proximity Read

General dimensions of human brain morphometry inferred from genome-wide association dataSemantic proximity Read

Genomic Structural Equation Modeling Reveals Latent Phenotypes in the Human Cortex with Distinct Genetic ArchitectureSemantic proximity Read

The Genetic Architecture of Brain Structure and Function: A Data-Driven Interpretation Using genomICASemantic proximity Read

Multivariate genome-wide association study on tissue-sensitive diffusion metrics highlights pathways that shape the human brainSemantic proximity Read

A large scale multivariate parallel ICA method reveals novel imaging-genetic relationships for Alzheimer's disease in the ADNI cohort.Semantic proximity Read

Genetic architecture of the white matter connectome of the human brainSemantic proximity Read

Multivariate genome-wide association study on tissue-sensitive diffusion metrics identifies key molecular pathways for axonal growth, synaptogenesis, and astrocyte-mediated neuroinflammationSemantic proximity Read

BiGen: Integrative Clinical and Brain-Imaging Genetics Analysis Using Structural Equation ModelSemantic proximity Read

Genomic structural equation modeling reveals latent phenotypes in the human cortex with distinct genetic architecture.Semantic proximity Read

A Molecular Basis of Human Brain ConnectivitySemantic proximity Read