Article

Convex approaches to isolate the shared and distinct genetic structures of subphenotypes in heterogeneous complex traits

2025-04-16

Abstract excerpt

<h4>ABSTRACT</h4> Groups of complex diseases, such as coronary heart diseases, neuropsychiatric disorders, and cancers, often display overlapping clinical symptoms and pharmacological treatments. The shared associations of genetic variants across diseases has the potential to explain their underlying biological processes, but this remains poorly understood. To address this, we model the matrix of summary statistic...

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Literature Corpus work: 8eafbdf8-0703-5850-8e4f-10d294829559
DOI: 10.1101/2025.04.15.25325870

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