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Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells.

Cell stem cell - 2 May 2013

Maroof Asif M, Keros Sotirios, Tyson Jennifer A, Ying Shui-Wang, Ganat Yosif M, Merkle Florian T, Liu Becky, Goulburn Adam, Stanley Edouard G, Elefanty Andrew G, Widmer Hans Ruedi, Eggan Kevin, Goldstein Peter A, Anderson Stewart A, Studer Lorenz

Abstract excerpt

Human pluripotent stem cells are a powerful tool for modeling brain development and disease. The human cortex is composed of two major neuronal populations: projection neurons and local interneurons. Cortical interneurons comprise a diverse class of cell types expressing the neurotransmitter GABA. Dysfunction of cortical interneurons has been implicated in neuropsychiatric diseases, including schizophrenia,...

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Identifiers

PMID: 23642365
DOI: 10.1016/j.stem.2013.04.008
PMCID: PMC3681523

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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