Article

Human monoclonal antibodies that target the SFTSV glycoprotein Gn head from four neutralizing epitope groups

2025-11-30

Abstract excerpt

<h4>SUMMARY</h4> Severe fever with thrombocytopenia syndrome virus (SFTSV) is a lethal bunyavirus lacking approved countermeasures. From SFTS survivors, we isolate 84 human monoclonal antibodies (mAbs) against the viral glycoproteins Gn and Gc. Gn-specific mAbs demonstrate superior neutralization breadth and potency compared to the restricted neutralizing activity observed with Gc. Using a high-throughput yeast d...

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Literature Corpus work: ccaa451b-7329-5361-8173-a805b4c29cdb
DOI: 10.1101/2025.11.26.690690

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