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Mechanistic basis for potent neutralization of Sin Nombre hantavirus by a human monoclonal antibody

15 Jun 2023

Abstract excerpt

Abstract Rodent-borne hantaviruses are prevalent worldwide and upon spillover to human populations, cause severe disease for which no specific treatment is available. A potent antibody response is key for recovery from hantavirus infection. Here we study a highly neutralizing human monoclonal antibody, termed SNV-42, which was derived from a memory B cell isolated from an individual with previous Sin Nombre virus...

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PMID: 37322112
DOI: 10.1038/s41564-023-01413-y

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