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Cryo-EM structure of severe fever with thrombocytopenia syndrome virus

10 Oct 2023

Abstract excerpt

The severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne human-infecting bunyavirus, which utilizes two envelope glycoproteins, Gn and Gc, to enter host cells. However, the structure and organization of these glycoproteins on virion surface are not yet known. Here we describe the structure of SFTSV determined by single particle reconstruction, which allows mechanistic insights into bunyavirus...

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PMID: 37816705
DOI: 10.1038/s41467-023-41804-7

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