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Structural and mechanistic basis of neutralization by a pan-hantavirus protective antibody

14 Jun 2023

Abstract excerpt

Emerging rodent-borne hantaviruses cause severe diseases in humans with no approved vaccines or therapeutics. We recently isolated a monoclonal broadly neutralizing antibody (nAb) from a Puumala virus-experienced human donor. Here, we report its structure bound to its target, the Gn/Gc glycoprotein heterodimer comprising the viral fusion complex. The structure explains the broad activity of the nAb: It recognizes...

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PMID: 37315110
DOI: 10.1126/scitranslmed.adg1855

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