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Preservation of Human Colonic Stem Cells Requires an ERK Dynamics Checkpoint Mediated by AKT

2026-04-05

Abstract excerpt

<h4>ABSTRACT</h4> Colonic stem cells reside in a microenvironment enriched in epidermal growth factor, which is essential for their survival and can activate both PI3K-AKT and MAPK-ERK pathways. This predicts co-activation of both pathways within the growth factor-high stem cell compartment at the base of crypts. However, in patient-derived human colonic organoids and normal human tissue, stem cells maintain robu...

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Literature Corpus work
cc996456-fad4-5edd-bd19-a9cca419248e
DOI
10.64898/2026.04.02.715982
Open publication

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Preservation of Human Colonic Stem Cells Requires an ERK Dynamics Checkpoint Mediated by AKTDOI 10.64898/2026.04.02.715982
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