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A tunable human intestinal organoid system achieves controlled balance between self-renewal and differentiation

2 Jan 2025

Abstract excerpt

A balance between stem cell self-renewal and differentiation is required to maintain concurrent proliferation and cellular diversification in organoids; however, this has proven difficult in homogeneous cultures devoid of in vivo spatial niche gradients for adult stem cell-derived organoids. In this study, we leverage a combination of small molecule pathway modulators to enhance the stemness of organoid stem...

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PMID: 39747097
DOI: 10.1038/s41467-024-55567-2

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