Article

Macrophages inhibit <i>Coxiella burnetii</i> by the ACOD1-itaconate pathway for containment of Q fever

2022-05-11

Abstract excerpt

Infection with the intracellular bacterium Coxiella (C.) burnetii can cause chronic Q fever with severe complications and limited treatment options. Here, we identify the enzyme cis- aconitate decarboxylase 1 (ACOD1 or IRG1) and its product itaconate as protective host immune pathway in Q fever. Infection of mice with C. burnetii induced expression of several anti-microbial candidate genes, including Acod1 . In...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: de4e4ec1-ce30-5d88-b755-94e36fc01cff
DOI: 10.1101/2022.05.10.491306

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Macrophages inhibit <i>Coxiella burnetii</i> by the ACOD1-itaconate pathway for containment of Q feverDOI 10.1101/2022.05.10.491306Read

TNF and type I IFN induction of the IRG1-itaconate pathway restricts <i>Coxiella burnetii</i> replication within mouse macrophagesSemantic proximity Read

IRG1 controls host responses to restrict <i>Mycobacterium tuberculosis</i> infectionSemantic proximity Read

From neglected to dissected: How technological advances are leading the way to the study of Coxiella burnetii pathogenesis.Semantic proximity Read

The aconitate decarboxylase 1/itaconate pathway modulates immune dysregulation and associates with cardiovascular disease markers in SLESemantic proximity Read

Human iPSC derived alveolar macrophages reveal macrophage subtype specific functions of itaconate in <i>M. tuberculosis</i> host defenseSemantic proximity Read

<i>Coxiella burnetii</i> deubiquitinates host TRAF6 to modulate the macrophage innate immune responseSemantic proximity Read

Life on the Outside: The Rescue of Coxiella burnetii from Its Host CellSemantic proximity Read

Coxiella burnetii Employs the Dot/Icm Type IV Secretion System to Modulate Host NF-κB/RelA Activation.Semantic proximity Read

Virulent<i>Coxiella burnetii</i>pathotypes productively infect primary human alveolar macrophagesSemantic proximity Read

<i>Coxiella burnetii</i> establishes a small cell variant (SCV)-like persistent form to survive adverse intracellular conditionsSemantic proximity Read

CYP1B1-AS1 regulates CYP1B1 to promote Coxiella burnetii pathogenesis by inhibiting ROS and host cell deathSemantic proximity Read

EirA Is a Novel Protein Essential for Intracellular Replication of Coxiella burnetii.Semantic proximity Read