Article

Neuropathology in Mice Expressing Human α-Synuclein

2000-08-15

Abstract excerpt

The presynaptic protein α-synuclein is a prime suspect for contributing to Lewy pathology and clinical aspects of diseases, including Parkinson9s disease, dementia with Lewy bodies, and a Lewy body variant of Alzheimer9s disease. α-Synuclein accumulates in Lewy bodies and Lewy neurites, and two missense mutations (A53T and A30P) in the α-synuclein gene are genetically linked to rare familial forms of Parkinson9s d...

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Literature Corpus work: 66d90b92-6fa0-549e-9fd4-4ff541a6cacd
DOI: 10.1523/jneurosci.20-16-06021.2000

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