Article

Tetraploidy-linked sensitization to CENP-E inhibition in human cells

2022-08-21

Abstract excerpt

Tetraploidy caused by whole-genome duplication is a hallmark of cancer cells, and tetraploidy-selective cell growth suppression is a potential strategy for targeted cancer therapy. However, how tetraploid cells differ from normal diploids in their sensitivity to anti-proliferative treatments remains largely unknown. In this study, we found that tetraploid cells are significantly more susceptible to inhibitors of a...

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Literature Corpus work: cc72a2ed-c0b0-5df2-b4c5-688dba1f33dd
DOI: 10.1101/2022.08.21.504625

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