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Article

Tetraploidy‐linked sensitization to CENP‐E inhibition in human cells

23 Jan 2023

Abstract excerpt

Tetraploidy is a hallmark of cancer cells, and tetraploidy-selective cell growth suppression is a potential strategy for targeted cancer therapy. However, how tetraploid cells differ from normal diploids in their sensitivity to anti-proliferative treatments remains largely unknown. In this study, we found that tetraploid cells are significantly more susceptible to inhibitors of a mitotic kinesin (CENP-E) than are...

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PMID: 36688680
DOI: 10.1002/1878-0261.13379

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